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| T2*-weighted (a and b), T2-weighted (c and d), and FLAIR (e and f) images of the medial temporal lobe obtained at 1.5 T (a, c, and e) and 7 T (b, d, and f), illustrating the strikingly improved resolution that high-field MRI offers. Reprinted from Theysohn et al.: The human hippocampus at 7 T-in vivo MRI, Hippocampus 19:1–7, 2009, copyright 2008, Wiley-Liss, Inc. |
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| Five AD hippocampal specimens (A1–A5) and one normal control (N4) are shown. Note the signal voids in AD specimens along the hippocampus compared with the lack of such signal voids in the normal control. The border between field CA1 and the subiculum is indicated by the white line derived from coregistered acetylcholine, myelin, and Nissl staining. The variability in their locations relative to the medial aspect of the hippocampal body illustrates the challenges inherent in in vivo imaging studies of hippocampal subregions. Reprinted from Neurobiology of Aging, vol 36, Zeineh M, Chen Y, Kitzler HH, Hammond R, Vogel H, Rutt BK, “Activated iron-containing microglia in the human hippocampus identified by magnetic resonance imaging in Alzheimer’s disease,” pp 2483–2500, 2015, with permission from Elsevier. |
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| 7-T FLAIR MRI in the (left to right) transverse (left), sagittal (center), and coronal (right) views. The arrow is pointing to a microinfarct. Reprinted with permission from van Rooden S, Goos JD, van Opstal AM, Versluis MJ, Webb AG, Blauw GJ, et al: Increased number of microinfarcts in Alzheimer disease at 7-T MR imaging. Radiology 270:205–211, 2014. |
